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006), and female physicians' patients received their first intravenous (IV) antibiotic dose later than male physicians' patients in the ED ( = .003). Our study indicates that the sex of the attending physician may affect the chosen level of care and antibiotic treatment, and that admitted male patients with CAP were more seriously ill than admitted female patients with CAP.Our study indicates that the sex of the attending physician may affect the chosen level of care and antibiotic treatment, and that admitted male patients with CAP were more seriously ill than admitted female patients with CAP. -like acute lymphoblastic leukemia (ALL) is a high-risk disease with a complex genomic background. Though extensively studied, data on the frequency and mutual associations of present mutations are still incomplete in adult patients. This retrospective study aims to map the genomic landscape of B-other ALL in a cohort of adult patients with a focus on the -like ALL subtype. We analyzed bone marrow and peripheral blood samples of adult B-other ALL patients treated consecutively at three major Czech teaching hospitals. Samples were analyzed by cytogenetic methods, gene expression profiling, multiplex ligation-dependent probe amplification (MLPA), and next-generation sequencing (NGS). Fifty-eight B-other ALL patients (not , -rearranged, , , or iAMP21) were included in the study. Median follow-up was 23.8months. Samples from 33 patients were available for a gene expression analysis, 48.9% identified as -like ALL. Of the -like ALL cases, 18.8% harbored and 12.5% fusion gene. We observed and identifies a number of novel gene variants.Since chronic dyslipidemia and inflammation play a major role in the etiopathogenesis of atherosclerotic plaque, we investigated the effects of a 7-week exercise on the serum lipid profile, plasma atherogenic index (PAI), and inflammatory biomarkers interleukin (IL), tumor necrosis factor (TNF)-α, and monocyte chemoattractant protein (MCP)-1 in male soccer players. Methods The participants in this study were 22 healthy male soccer players aged 19-25 years. IL-1β, IL-6, IL-10, TNF-a, MCP-1, and lipid profile were recorded before and after the program. PAI was calculated as log (TG/HDL-C), where TG is triglyceride and HDL-C is high-density lipoprotein cholesterol. Results There were significant decreases in post-exercise IL-6, TNF-α, and MCP-1 (for all, p less then .05). C1889 Compared to the pretest values, there were significant decreases in posttest total cholesterol (TC), TGs, low-density lipoprotein (LDL), non- high-density lipoprotein cholesterol (non-HDL-C), and PAI (for all, p less then .05). In contrast, HDL-C values increased after exercise (p less then .001). After exercise training TC, TGs, LDL-C, non-HDL-C, and PAI decreased and HDL-C increased, indicating improvement in parameters of dyslipidemia. The decreases in IL-6, TNF-α, and MCP-1 suggest a decrease in systemic inflammation.Purpose To analyse clinico-microbiological profile, antimicrobial susceptibilities, and visual prognostic factors in post-traumatic endophthalmitis (PTE).Methods Retrospective clinico-microbiological data analysis for five years (2014-18). Prognostic factors for visual outcomes were analysed by multivariate logistic regression analysis.Results Four hundred and eighteen patients with clinically diagnosed PTE were analysed. Culture positivity was found in 46.7% samples (44.5% vitreous, 83.3% non-vitreous). Pathogens isolated were Gram positive cocci (GPC, 49.3%, good susceptibility to vancomycin/cefazolin), Gram negative bacilli (GNB, 28.1%, less then 90% susceptibility to all antibiotics and 25.8% multidrug resistance), Gram positive bacilli (13.1%) and fungi (9.5%). Poor visual prognosis was associated with culture positivity, fungal or polymicrobial PTE, poor view of fundus and presence of membranes on ultrasound scans.Conclusion GPC and GNB are the predominant pathogens in PTE, with GNB most commonly multidrug resistant. Culture positivity, polymicrobial and fungal PTE, poor view of fundus and vitreous membranes are markers of poor visual outcome.The maximum Von-Mises stress analysis introduced by dynamic body load on hip implant was considered in this research. The different hip stem shapes including elliptical, circular and oval cross sections with various configurations and material properties including that of Ti-6Al-4V, Co-Cr-Mo and SS316L alloys were simulated by 3D computational analysis to evaluate the "stress-shielding effect" on the implant surface. In order to categorise the various shapes and materials based on "stress-shielding effect", a factor called "stress distribution" (SD) was developed. Results showed that the highest Von-Mises stress levels are attributed to the elliptical cross-section, whereas oval cross-sections comprised the least figures with certain stem profiles. In terms of SD factor, titanium alloy with elliptical cross section indicated the lowest level, while the better results specified to the oval shape. Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Although demographic and clinical parameters such as sex, age, comorbidities, genetic background and various biomarkers have been identified as risk factors, there is an unmet need to predict the risk and onset of severe inflammatory disease leading to poor clinical outcomes. In addition, very few mechanistic biomarkers are available to inform targeted treatment of severe (auto)-inflammatory conditions associated with COVID-19. Calprotectin, also known as S100A8/S100A9, MRP8/14 (Myeloid-Related Protein) or L1, is a heterodimer involved in neutrophil-related inflammatory processes. In COVID-19 patients, calprotectin levels were reported to be associated with poor clinical outcomes such as significantly reduced survival time, especially in patients with severe pulmonary disease. Pubmed was searched using the following keywords Calprotectin + COVID19, S100A8/A9 +COVID19, S100A8 +COVID-19, S100A9 +COVID-19, MRP8/14 +COVID19; L1 +COVID-19 between May 2020 and 8 March 2021. The results summarized in this review provide supporting evidence and propose future directions that define calprotectin as an important biomarker in COVID-19. Calprotectin represents a promising serological biomarker for the risk assessment of COVID-19 patients.Calprotectin represents a promising serological biomarker for the risk assessment of COVID-19 patients.