With the advent of large astronomical surveys plus multi-messenger astronomy, both automatic detection and classification of Type Ia supernovae have been addressed by different machine learning techniques. In this article we present three solutions aimed at the future spectrometer of the KDUST project, within a scope of benchmark, considering three different methodologies. FICZ cell line The systems presented here are the following CINTIA (based on hierarchical neural network architecture), SUZAN (which incorporates the solution known as fuzzy systems) and DANI (based on Deep Learning with Convolutional Neural Networks). The characteristics of the systems are presented and the benchmark is performed considering a data set containing 15.134 spectra. The best performance is obtained by the DANI architecture which provides 96% accuracy in the classification of Type Ia supernovae in relation to other spectral types.International Scientific Optical Network (ISON) is an open international voluntary project specializing in observations of the near-Earth space objects. Observatories collaborating with ISON provide the global coverage and successfully combine the observations of the space debris and asteroids. The network includes more than 50 telescopes of 27 observatories in 15 countries and has been working since 2005. ISON monitors the whole GEO region and tracks the objects at GEO, GTO, HEO and LEO. ISON data allowing maintenance of the database of the space objects orbits, validating space debris population model and providing conjunction assessment analysis for satellites at high orbits. ISON develops the technology of asteroid survey with small telescopes and arranges regular photometry observations of near-Earth asteroids (NEA) to investigate the YORP effect, search new binary NEAs, and support radar experiments. Although transplanting two kidneys from a single donor to two recipients has some advantages, the right and left kidneys are not anatomically identical; thus, a surgical procedure considering the anatomical features of the donor kidneys is needed when transplanting them into the opposite renal fossae. Based on vast experience, the surgical details of pig orthotopic kidney transplantation from one donor to two recipients was reported. When the right kidney was transplanted to the left renal fossa, the graft was inverted upside down, not backwards, thus ensuring that the anteroposterior relationship of the renal vessels was maintained and anatomically natural vascular anastomosis could be performed. Using this technique, we could have developed a pig experimental model that is safe and has a high success rate, even for researchers in the middle of their training. This technique of inverting the graft upside down was reported in human kidney transplantation to make vascular anastomosis easier. In pig orthotopic kidney transplantation from one donor to two recipients, an anatomically natural vascular anastomosis could be performed via inverted grafting when the right kidney was transplanted into the left renal fossa.In pig orthotopic kidney transplantation from one donor to two recipients, an anatomically natural vascular anastomosis could be performed via inverted grafting when the right kidney was transplanted into the left renal fossa. To evaluate clinical outcome following minimally invasive plate osteosynthesis (MIPO) associated with percutaneous transplantation of allogeneic adipose-derived mesenchymal stem cells (AD-MSC) at the tibial fracture site in dogs. Thirty-six dogs presenting with nonarticular complete tibial fracture were included in this study. All fractures were treated by the same MIPO technique. The animals were divided in group 1 (n = 20) received a percutaneous application of 3 × 106 AD-MSC at the fracture site and group 2 (n = 16) did not receive any adjuvant treatment. Postoperative radiographic examinations were made at 15, 30, 60, 90 and 120 days. Fifty-eight percent of the patients were classified as skeletally immature. The median weight of the animals was 18.8 kg. The mean radiographic union time differed statistically between the AD-MSC group (28.5 days) and the control group (70.3 days). Sixty percent of dogs in group 1 and 56.25% of the group 2 were considered immature. The use of allogeneic AD-MSC cell therapy and MIPO is a safe, viable and effective technique for promoting bone healing in nonarticular tibial fractures in dogs.The use of allogeneic AD-MSC cell therapy and MIPO is a safe, viable and effective technique for promoting bone healing in nonarticular tibial fractures in dogs. To evaluate the influence of autonomic vagal and splenic activities on renal histomorphometric aspects in obese rats. Thirty male Wistar rats were used, of which, 24 received subcutaneous injections of monosodium glutamate (MSG) during the first 5 days of life (4 g/kg body weight) and six control animals received injections of saline solution (CON). Five experimental groups were organized (n = 6/group) falsely-operated control (CON-FO); falsely-operated obese (MSG-FO); vagotomized obese (MSG-VAG); splenectomized obese (MSG-SPL); vagotomized and splenectomized obese (MSG-VAG-SPL). The MSG-FO group animals showed a significant reduction in body weight and nasal-anal length when compared to CON-FO group animals (p < 0.05). The MSG-VAG-SPL group showed significant reduced in most biometric parameters associated with obesity. Falsely-operated obese animals showed a significant reduction in renal weight, glomerular diameters, glomerular tuff and capsule areas and Bowman's space compared to CON-FO group animals (p < 0.05). There was a significant reduction in diameter, glomerular tuft and capsule areas, and Bowman's space in MSG-VAG, MSG-SPL, MSG-VAG-SPL groups when compared to the MSG-FO group. Vagotomy associated with splenectomy induces a reduction in the adiposity and causes histological changes in the kidney of obese rats.Vagotomy associated with splenectomy induces a reduction in the adiposity and causes histological changes in the kidney of obese rats. To present a model to reproduce the clinical condition, in order to better understand the pathophysiology of neurological impairment related to intoxication. Twenty-five Wistar rats were used and divided into five groups Shaw group (WHI), water gavage group (WGV), star fruit gavage group (SGV), nephropathic group with water gavage (NPW), nephropathic group with star fruit gavage (NPS).Nephropathic groups were submitted to surgery, developing nephropathy. After surgery, they received preestablished gavage with star fruit juice or water. The electroencephalographic records were evaluated in the experimental nephropathic group that received gavage of star fruit juice. To assess the induction of neurotoxicity using electroencephalographic data, the NPS group demonstrated the presence of epileptic seizures associated with star fruit intoxication. The experimental model herein presented was adequate to reproduce the clinical condition experienced by nephropathic patients who ingest star fruit juice, establishing, thus, an experimental model utterly important for the study of the neurological toxicity process.