Allocation of micromotion complied with case specific anticipations. The novel pin-sleeve sensors transmitted interface micromotion to the accessible periphery as desired. The measurement method enables instructive insights into three-dimensional bone-implant micromotion and may prospectively be used to evaluate different implant systems.Nanotechnology has recently gained fame for its extensive use in biomedical applications particularly in magnetic fluid hyperthermia (MFH) of tumors. The magnetic nanoparticles (MNPs) are usually injected into the tumor either intravenously or through direct needle injection. Depending on the location of the tumor, the needle approach may not be appropriate and in the case, when the nanoflow rate is higher, it may produce cracks in the tumor. In this scenario, the intravenous approach following the enhanced permeation and retention effect (EPR) effect proves advantageous. In this paper, we have simulated the EPR effect of nanofluid flowing from blood vessels to the tumor through epithelial cells spacing and then its diffusion in the tumor interstitium using COMSOL Multiphysics. The velocity in the blood vessel and diffusion in the tumor have been simulated and analyzed using Finite Element Method (FEM) based models of Navier-Stokes equations and convection-diffusion equation. The simulation results show that the velocity and concentration are higher in the blood vessel and it decreases slowly while moving through epithelial spacing to the tumor interstitium. The heat transfer in the tumor interstitium is simulated and analyzed for temperature distribution quantitatively.The continuous improvement of minimally invasive hip endoprostheses surgery comes with a change in geometries of surgery instruments like the broach handles. Consequently, depending on the handles' curvature this results in a deviation between handle and femoral axis. Therefore, this study aimed to prove the influence of different handles' curvatures on the preparation of implant site and acting forces and moments in this process. Five femoral models attached to different handles (double-curved, single-curved, straight) were locked in a drop-weight device with standardize implantation forces and moments and five strokes were measured for each possible combination. Distribution of force and moment components was dependent on the handle's curvature, where the lowest variation from the standard force values was by the straight one (av15.2% ± 0.5%) and the strongest discrepancies were exhibit by the double-curved one (av54.3% ± 0.1%.). Moment values have also shown this trend with the lowest variation (12.4%-23.3%) by the straight one and the highest discrepancies (56,6%-90.9%) by the double-curved one. Results show that unguided axial impact introduces unwanted transverse forces and moments into the femur. Therefore, broach handles should be modified accordingly so that minimally invasive surgery remains feasible but unwanted forces or moments can still be compensated.Motive Metallic fibre networks and their mechanical behaviour are only insufficiently understood. https://www.selleckchem.com/products/bda-366.html In this particular field of research, the use of nano-CT scans offers advanced opportunities for the optimised planning of experimental work and component design. Several novel applications will benefit from this research; in particular, tissue engineering applications where a controlled and reproducible mechanical stimulus on cells is required can make use of these components. MethodFor the present study, the geometry of metallic fibre network samples is measured and digitalised through the use of nano-CT scan protocols and adequate radiological post-processing steps. Fibre medial axes are transferred into finite element assemblies and are exposed to magnetic actuation models. Network displacement of input geometries is quantified by averaging of node displacement fields. Key resultsComplex 3D deformation fields with regions of tension, shear, and compression are obtained. Results from a previous study about matrix material deformation can be confirmed in this study for greater sample geometries. The strain magnitude is not uniform across the samples; several influencing parameters and deformation patterns are identified. A simple analytical model can be presented which quantifies the material deformation. ConclusionsNano-CT scans provide an efficient radiological tool in the planning of relevant experimental procedures. The present study confirms the general usability of fibre networks for the contactless creation of 3D strain fields in tissue engineering. Mechanical effects in tissue growth stimulation known from experimental work are obtained numerically for the investigated assemblies. Further work about the mechanical effects in tissue cultures appears highly worthwhile.Injuries on lower-extremity joints were caused by high impact force in parachuting landing. Knee brace was used to protect knee by restraining motion of knee. Backpack was necessary in parachuting landing and would increase lower-extremity joints injuries. This study aimed to analyze kinematics and kinetics of hip, knee and ankle for investigating multi-joint protection of knee brace for those joints in parachuting landing with backpack. Seven participants landed from 120 cm height. Kinematics and kinetics of hip, knee and ankle were analyzed. It was found that without backpack knee brace decreased angular displacements of hip (12.0%), knee (10.3%) and ankle (18.6%) on sagittal plane and angular velocities of hip (11.9%), knee (6.6%) and ankle (20.9%) on sagittal plane. With backpack, knee brace decreased angular displacement (5.5%) and angular velocity of knee (6.2%) on sagittal plane, but did not significantly influence those of hip and ankle on sagittal plane. Ground reaction force, joint moments and joint energy absorptions were not significantly influenced with knee brace. In conclusion, in parachuting landing without backpack, knee brace could provide multi-joint protection for hip, knee and ankle. In parachuting landing with backpack, knee brace could still protect knee, but could not protect hip and ankle.