The inclusion of physical health dimensions was perceived as positive, but some patients considered the descriptive system too generic. The results indicate that these patients in general could self-report their health in a meaningful way with the EQ-5D-Y-5L instrument.The inclusion of physical health dimensions was perceived as positive, but some patients considered the descriptive system too generic. The results indicate that these patients in general could self-report their health in a meaningful way with the EQ-5D-Y-5L instrument. Health care teams are increasingly forced to navigate complex challenges to achieve their collective aim of delivering high-quality, safe patient care. The teamwork literature has struggled to develop strategies that promote effective adaptive behaviours among health care teams. In part, this challenge stems from the fact that truly collective adaptive behaviour requires members of the teams to abandon the human urge to act self-sufficiently. Nature contains striking examples of collective behaviour as seen in social insects, fish and bird colonies. This collective behaviour is known as Swarm Intelligence (SI). SI remains poorly described in the health care team literature and its potential benefits hidden. In this cross-cutting edge paper, I explore the principles of SI as they pertain to systemic or collective adaptation in human teams. In particular, I consider the principles of trace-based communication and collective self-healing and what they might offer to team adaptation researchers in medical eduallowing teams to rely on indirect communication and to be interchangeable might create discomfort to our ways of thinking, teams outside health care are demonstrating their value to advance human teamwork. SI offers a helpful analogy and a constructive language for thinking about team adaptation.In the literature of statistical analysis with missing data there is a significant gap in statistical inference for missing data mechanisms especially for nonmonotone missing data, which has essentially restricted the use of the estimation methods which require estimating the missing data mechanisms. Nanchangmycin molecular weight For example, the inverse probability weighting methods (Horvitz & Thompson, 1952; Little & Rubin, 2002), including the popular augmented inverse probability weighting (Robins et al, 1994), depend on sufficient models for the missing data mechanisms to reduce estimation bias while improving estimation efficiency. This research proposes a semiparametric likelihood method for estimating missing data mechanisms where an EM algorithm with closed form expressions for both E-step and M-step is used in evaluating the estimate (Zhao et al, 2009; Zhao, 2020). The asymptotic variance of the proposed estimator is estimated from the profile score function. The methods are general and robust. Simulation studies in various missing data settings are performed to examine the finite sample performance of the proposed method. Finally, we analysis the missing data mechanism of Duke cardiac catheterization coronary artery disease diagnostic data to illustrate the method. Oral mucositis (OM) is one of the main adverse effects of the chemotherapeutic agent methotrexate (MTX). To evaluate the relationship of OM with MTX metabolism time and other toxicities in childhood, cancer patients receiving high-dose of methotrexate (HD-MTX). Seventy-seven childhood patients receiving HD-MTX for treatment of leukaemia, osteosarcoma or lymphoma were evaluated. MTX serum level, hepatic and renal function parameters, and presence and intensity of OM were analysed. The patients were submitted to 255 cycles of chemotherapy. OM was diagnosed in 191 (74.9%) cycles. Of these, 119 (46.6%) presented ulcerative lesions. Lymphoma was associated with severe OM (P=.01). OM was associated with higher serum levels of aspartate aminotransferase (P=.006), alanine aminotransferase (P=.04) and creatinine (P=.008). Increase of one unit of total bilirubin and indirect bilirubin associated, respectively, with 11% and 39% higher prevalence of OM. For each increase of one unit of creatinine serum level, it was observed a 37% higher prevalence of OM in patients with lymphoma. No association was found between delayed excretion of MTX and OM development. OM is a prevalent complication of childhood cancer patients receiving HD-MTX. Renal and hepatic toxicity could be considered risk factors for OM, especially in patients with lymphoma.OM is a prevalent complication of childhood cancer patients receiving HD-MTX. Renal and hepatic toxicity could be considered risk factors for OM, especially in patients with lymphoma.Heliotropium indicum Linn is a leafy vegetable that has been used in Bangladeshi ethnomedicinal practices. The attenuation effect of H. indicum supplementation was evaluated in high carbohydrate high-fat (HCHF) diet-induced obesity and associated disorders in 8-weeks-old female Wister rats. H. indicum significantly (p less then .05) prevented weight gain and improved glucose intolerance in obese rats. It also significantly (p less then .05) ameliorated lipid parameters in HCHF diet fed rats preventing hypercholesterolemia and hypertriglyceridemia, resulting in improved the artherogenic index (AI). Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) activities were brought to normal by H. indicum. It significantly elevated superoxide dismutase (SOD) and catalase (CAT) activities as well as increased reduced glutathione (GSH) concentration in liver. The intense liver fat deposition was seen in HCHF fed rats which were relatively low in H. indicum fed rats. Therefore, H. indicum has the ability to prevent obesity and associated metabolic disorders. PRACTICAL APPLICATIONS Obesity and associated metabolic disorders are the most common threats to public health. Modern lifestyle and food habits are the main causes behind this malice, and the introduction of functional foods in daily diet is proved to be highly beneficial. Results of this study demonstrated that H. indicum can effectively attenuate obesity and its associated metabolic complications. Therefore, the current study has the merits to promote scientific knowledge of the dietary application of H. indicum as a functional food among the community.