The amalgamation of the ORL Research Societies as a Specialty Group within ENT-UK to organise and run the national research agenda is likely to result in a more cohesive group with financial stability and a secure and stable environment. This article is protected by copyright. All rights reserved.Breast cancer is a common malignant tumor suffered predominantly by women worldwide, which results in serious levels of morbidity and mortality. To control the effects of the cancer, it is critically important to elucidate the pathophysiological processes by which it occurs and develops. Reports have demonstrated that long noncoding RNAs perform a critical role in the development and metastasis of cancers. The lncRNA TTN-AS1 is considered carcinogenic. Nevertheless, the importance and biological functions of TTN-AS1 in breast cancer require greater exploration. In the current paper, we observed that TTN-AS1 expression was significantly upregulated in breast cancer tissues/cells compared with those that are healthy. TTN-AS1 enhanced the proliferation, migration, invasion, and epithelial-mesenchymal transformation of breast cancer cells. Furthermore, a direct target of TTN-AS1, miR-139-5p was negatively regulated. In addition, zinc finger E-box binding homeobox 1 (ZEB1) is an important nuclear transcription factor, the expression of which is increased in multiple tumors. Here, we also found that ZEB1 is a target of miR-139-5p, of which TTN-AS1 could regulate the expression through competition with miR-139-5p. That is, TTN-AS1 promoted proliferation and invasion of breast cancer cells by interaction with the miR-139-5p/ZEB1 axis. In conclusion, the present study aimed to illustrate the significance of TTN-AS1 in breast cancer metastasis and contribute to potentially innovative strategies for its treatment. © 2020 Wiley Periodicals, Inc.Chronic lymphocytic leukemia (CLL), a severe problem all over the world and represents around 25% of all total leukemia cases, is generating the need for novel targets against CLL. Wnt signaling cascade regulates cell proliferation, differentiation, and cell death processes. Thus, any alteration of the Wnt signaling pathway protein cascade might develop into various types of cancers, either by upregulation or downregulation of the Wnt signaling pathway protein components. In addition, it is reported that activation of the Wnt signaling pathway is associated with the transcriptional activation of microRNAs (miRNAs) by binding to its promoter region, suggesting feedback regulation. Considering the protein regulatory functions of various miRNAs, they can be approached therapeutically as modulatory targets for protein components of the Wnt signaling pathway. In this article, we have discussed the potential role of miRNAs in the regulation of Wnt signaling pathway proteins related to the pathogenesis of CLL via crosstalk between miRNAs and Wnt signaling pathway proteins. This might provide a clear insight into the Wnt protein regulatory function of various miRNAs and provide a better understanding of developing advanced and promising therapeutic approaches against CLL. © 2020 Wiley Periodicals, Inc.Incorporating heteroatoms in functional materials is an invaluable approach to modulate their properties, assuming a solid solution is formed. However, thorough understanding of key structural information on the resulting solid solution, such as the local environment of cations and vacancies, remains a challenge. Solid-state NMR (SSNMR) spectroscopy is a powerful structural characterization tool, very sensitive to the local environment. Due to the difficulty in signal acquisition and spectral interpretation, SSNMR spectroscopy is relatively less known to chemists and materials scientists. Herein, we present an introductory review to demonstrate how to use 89Y SSNMR spectroscopy to unravel the mystery of solid solutions. In general, 89Y chemical shift varies with different cation/vacancy arrangements in Y coordination spheres, providing ultrafine structural information in the atomic scale. As a case study and an extreme condition, the approach demonstrated in this review can be extended to other systems. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.A key component of research on human sentence processing is to characterize the processing difficulty associated with the comprehension of words in context. Models that explain and predict this difficulty can be broadly divided into two kinds, expectation-based and memory-based. In this work, we present a new model of incremental sentence processing difficulty that unifies and extends key features of both kinds of models. Our model, lossy-context surprisal, holds that the processing difficulty at a word in context is proportional to the surprisal of the word given a lossy memory representation of the context-that is, a memory representation that does not contain complete information about previous words. We show that this model provides an intuitive explanation for an outstanding puzzle involving interactions of memory and expectations language-dependent structural forgetting, where the effects of memory on sentence processing appear to be moderated by language statistics. Furthermore, we demonstrate that dependency locality effects, a signature prediction of memory-based theories, can be derived from lossy-context surprisal as a special case of a novel, more general principle called information locality. Copyright © 2020 The Authors. check details Cognitive Science published by Wiley Periodicals, Inc. on behalf of Cognitive Science Society (CSS).IMPORTANCE Atropine eyedrops are a promising treatment for slowing myopia progression in East Asian children. However, its effects on children in Australia, including those of non-Asian background, have not been well-studied. BACKGROUND The Western Australia Atropine for the Treatment of Myopia (WA-ATOM) study aims to determine the efficacy and long-term effects of low-dose atropine eyedrops in myopia control. This paper describes the study rationale, methodology, and participant baseline characteristics. DESIGN Single-centre, double-masked, randomised controlled trial. PARTICIPANTS Children (6-16 years) with spherical equivalent ≤ - 1.50D in each eye, astigmatism ≤1.50D, and myopia progression by ≥0.50D/year. METHODS Enrolled children were randomly assigned 21 to receive 0.01% atropine or placebo eyedrops. Participants are examined every six months during first three years of the study (2-year treatment phase followed by a 1-year washout phase), and then at a 5-year follow-up (two years after the end of the washout phase).