Psychological stress caused by epidemics among health care workers and implications for coping with the corona crisis a literature reviewObjectives COVID-19 has significantly changed the working and living conditions within a short period. Despite the milder course of the disease in comparison to other countries, employees in the German health care system are particularly affected by the massive impact of the disease on their professional and private lives. From a scientific point of view, summarized empirical evidence made during other epidemics and at the beginning of the COVID-19-pandemic is largely missing. Methods Narrative review article, literature search on PubMed database. Results A total of 56 studies were included, 35 of them on the SARS epidemic and seven on COVID-19; included studies reported overall increased stress levels, anxiety and PTSD symptoms due to health care work during various epidemics. Direct contact with patients, quarantine experiences and perceived health risks were further stress factors in epidemics. Participation in intervention studies enabled better management of epidemic-related situations. Conclusions Healthcare workers are exposed to high workloads because of epidemics, which can have a variety of adverse effects. Recommendations are made for dealing with periods of high exposure during the COVID-19-pandemic. Financial hardship can be a major cause of distress among persons with cancer, resulting in chronic stress and impacting physical and emotional health. This paper provides an analysis of the lived experience of cancer patients' financial hardship from diagnosis to post-treatment. In-depth interviews were conducted with 26 cancer survivors who reported financial hardship during and/or after treatment. The interviews were analyzed using Dedoose as an organizational tool, the life course perspective as an organizing theoretical framework, and a thematic analysis tool to answer our research questions. Our analysis identified that timing and sequencing of life transitions and stress proliferation furthered the process of financial stress over time. Cancer survivors do not experience financial toxicity as a singular process; the experience can be quite different depending on age and life transitions. These findings provide psychosocial oncology providers with a framework for identifying patients at risk for financial distress and addressing the critical needs related to their life stage.These findings provide psychosocial oncology providers with a framework for identifying patients at risk for financial distress and addressing the critical needs related to their life stage.This paper aims to explore how pervasive constructions regarding a person's sex and gender identity in society and law limit the human rights of persons with variations of sex characteristics. Societal culture promulgates a binary (male/female) gender ideal which includes standards of normality for our bodies. People who do not easily fit these culturally constructed norms, such as persons with variations of sex characteristics, encounter numerous difficulties. The legal conceptualisation of 'sex' according to the binary maintains the medicalisation of variations of sex characteristics and reinforces the focus on sex 'normalising' treatment of children who are too young to provide their informed consent. The paper makes use of Belgium as an illustration. Not only is comprehensive legal research concerning variations of sex characteristics absent in Belgium, but the country has also been responsive to human rights claims regarding sexual identity in recent years. With regards to the sex assigning or 'normalising' treatment of persons with variations of sex characteristics, this paper argues that by accepting the substitution of the child's informed consent for the opinion of the legal representative in the absence of urgent medical necessity, Belgian law fails to protect the former's right to bodily integrity and best interests.Virtual screening refers to the screening of active compounds based on a small-molecule database. This procedure can rapidly select active compounds with pharmaceutical properties from millions of molecules, thus considerably reducing the number of experimental screening compounds and cost of drug development and shortening the research cycle. In this paper, a pharmacophore screening method was used for virtual screening to determine new scaffold compounds with potential anticoagulant activities. The pharmacophore model (Model_01-20) was constructed in SYBYL-X 2.0 based on dabigatran derivatives (D1-D9) with micromolar to nanomolar activities and tested by decoy test method. Model_01 was selected to screen more than 1600 million compounds in the Zinc 12.0 database. Furtherly, molecular docking analysis and ADME prediction were conducted on more than 100,000 screened compounds. Finally, two compounds (Z-19 and Z-29) were selected for anticoagulant activity test in vitro, Compound Z-29 with tryptophan aurone structure was found possess anticoagulant effect and its IC50 = 22.9 ± 6.88 μM. ADME prediction results show that compound Z-29 features a high intestinal absorption rate, which is valuable for further in-depth research. The research results of this paper can be used for further structural modification and optimisation to guide the design and provide new ideas and methods for the discovery of new thrombin inhibitors. Communicated by Ramaswamy H. Sarma.Both ATP and inorganic polyphosphates (PolyP) appeared to be involved in the yeast energy homeostasis, in which plasma membrane PMA1 H+-АТРase plays one of the key roles. Acetylcysteine During biogenesis and functioning, the enzyme undergoes structural and regulatory phosphorylation. Aim of the work was to elucidate interconnection between functioning of the yeast PMA1 H+-АТРase carrying point substitutions that affected the enzyme structure-function relationship and its ability to be phosphorylated and PolyP metabolism. Effect of such replacements of phosphorylable and non-phosphorylable residues in three topologically and functionally different domains of the enzyme - membrane, extracytosolic, and C-terminal - on the metabolism of polyphosphates and distribution between short-, mid-, and long-chained PolyP fractions (PolyP1-PolyP4-5) has been studied. АТРase activity of membrane and most extracytosolic strains was noticeably lower comparing to the wild type. Of these mutants, three substitutions (L801A, E803A, E847A) have not caused significant changes in PolyP content regardless up to twofold drop of the ATPase activity; F796A with four-fold decreased activity has led to noticeable increase of mid-chained PolyP fractions.